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On the other hand, several reports suggest that CKMT2 is an important player in adipose tissue thermogenesis, that is, downregulation of Ckmt2 in adipose cells decreases phosphocreatine levels 38 , and silencing of 3 -adrenergic receptors in beige/brown adipose cells decreases both Ckmt1 and Ckmt2 expression 41
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